2-Hydroxymethyl oxolane

2-Hydroxymethyl oxolane - Names and Identifiers

Name	Tetrahydrofurfuryl alcohol
Synonyms	THFA 2-Oxolanemethanol Oxolane-2-methanol Tetrahydrofurfuryl a 2-Hydroxymethyl oxolane Tetrahydrofuryl Alcohol Tetrahydrofurfuryl alcohol Tetrahydrofuran-2-methanol Tetrahydro-2-furanmethanol Tetrahydrofurfruyl Alcohol tetrahydrofuran-2-ylmethanol TETRAHYDROFURFURYLIC ALCOHOL TETRAHYDROFURFURYL ALCOHOL FCC tetrahydro-2-furylmethanol tetrahydrofurfuryl alcohol
CAS	97-99-4
EINECS	202-625-6
InChI	InChI=1/C5H10O2/c6-4-5-2-1-3-7-5/h5-6H,1-4H2
InChIKey	BSYVTEYKTMYBMK-UHFFFAOYSA-N

2-Hydroxymethyl oxolane - Physico-chemical Properties

Molecular Formula	C5H10O2
Molar Mass	102.13
Density	1.054 g/mL at 25 °C (lit.)
Melting Point	-80 °C (lit.)
Boling Point	178 °C (lit.)
Flash Point	183°F
JECFA Number	1443
Water Solubility	soluble
Solubility	acetone: miscible(lit.)
Vapor Presure	2.3 mm Hg ( 39 °C)
Vapor Density	3.52 (vs air)
Appearance	Liquid
Color	Clear
Merck	14,9213
BRN	102723
pKa	14.44±0.10(Predicted)
Storage Condition	Store below +30°C.
Sensitive	Hygroscopic
Explosive Limit	1.5-9.7%(V)
Refractive Index	n20/D 1.452(lit.)
Physical and Chemical Properties	Characteristics of colorless liquid, slightly odor. Hygroscopic. boiling point 177~178 ℃ relative density 1.0544 refractive index 1.4517 flash point 75 ℃ solubility, chloroform and benzene miscible, insoluble in paraffin.
Use	Used as a solvent, also used as a raw material for the preparation of dihydrofuran, lysine, etc., and its esters are used as plasticizers

2-Hydroxymethyl oxolane - Risk and Safety

Risk Codes	R36 - Irritating to the eyes R62 - Possible risk of impaired fertility R61 - May cause harm to the unborn child
Safety Description	S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	NA 1993 / PGIII
WGK Germany	2
RTECS	LU2450000
TSCA	Yes
HS Code	29321300
Toxicity	LD50 orally in Rabbit: 1600 mg/kg

2-Hydroxymethyl oxolane - Nature

Open Data Verified Data

colorless liquid, slightly odorous. Hygroscopic. Flammable. Low toxicity. Miscible with water, ethanol, ether, acetone, chloroform and benzene, insoluble in paraffin. The relative density was 1. 0544. Boiling Point (look kPa) 177~178 °c. Refractive index 4517. Flash point 75 °c. Viscosity (25 °c) 5. 49MPA. s. Spontaneous ignition point 282.2.

Last Update：2024-01-02 23:10:35

2-Hydroxymethyl oxolane - Preparation Method

Open Data Verified Data

prepared by one-step hydrogenation of furfural or two-step hydrogenation of furfural via furfuryl alcohol.

a nickel-chromium-copper-based catalyst was used for one-step hydrogenation of furfural at a reaction temperature of 170-180 ° C. And a pressure of 7.35-10. 39MPa. The yield of this method is 70% ~ 80%. Ru02 can also be used as a catalyst in an amount of 2% of the mass of furfural, and the reaction is carried out at 80-100 ° C. And 3.92-4. 90MPA.
The two-step method uses a copper-nickel-Mercury-sulfur catalyst, and also uses Raney nickel or cobalt as a catalyst. When a Raney nickel or chromium compound is used as the catalyst, the temperature is 130 ° C. And the pressure is 9. 8MPa. In addition, nickel supported on diatomaceous earth may also be used as a catalyst.

Last Update：2022-01-01 10:56:59

2-Hydroxymethyl oxolane - Use

Open Data Verified Data

organic synthesis raw materials, can be prepared dihydrofuran, lysine, long-acting vitamin bi. Also used for the preparation of polyamide plastics, antifreeze, herbicides, pesticides. Their esters are used as plasticizers. Solvents for resins, paints and greases. Used as lubricant and dispersion in printing and dyeing industry
Drug. Also can be used as fatty acid Taro oil and some of the drug decolorization, deodorant.

Last Update：2022-01-01 10:56:58

2-Hydroxymethyl oxolane - Safety

Open Data Verified Data

low toxicity, the eyes, skin and mucous membranes have a certain degree of irritation. LD50 mice were administered with 2500 mg/kg and rats were administered with ~ 4000mg/kg. Protection Measure see furfuryl alcohol.
clean iron drum packaging. 200kg per barrel. Store in a cool, dry and ventilated place. Fireworks are strictly prohibited. According to the provisions of flammable chemicals storage and transportation.

Last Update：2022-01-01 10:56:59

2-Hydroxymethyl oxolane - Reference Information

FEMA	3056 \| TETRAHYDROFURFURYL ALCOHOL
LogP	-0.14 at 24.7℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
content analysis	measured by gas chromatography (GT-10-4) using a polar column method.
toxicity	LD50 2500-4000mg/kg (rat). GRAS(FEMA).
Use limit	is moderately limited (FDA,§ 172.515,2000).
Use	is used as a solvent and also as a raw material for the preparation of dihydrofuran, lysine, etc, its esters are used as plasticizers GB 2760-1996 for the permitted use of flavorants. used in the preparation of succinic acid, pentanediol, Tetrahydrofuran, pyran, etc., also used as a solvent for coatings, resins and oils. In the printing and dyeing industry, it is used as a lubricant, a dispersant, a decolorizing agent for pharmaceuticals, a deodorizing agent, and a raw material for organic synthesis such as plasticizers, herbicides, and pesticides. Tetrahydrofuran methyl bromide was obtained by bromination of tetrahydrofurfuryl alcohol, and sodium thiosulfate was prepared by substitution of sodium thiosulfate. It is the raw material of long-acting vitamin B1 (furylthiamine). solvents for resins and oils. Oxidation of dyes and rubber. Manufacture of esters. Gelatin solution stabilizer. Wetting agent for printing and dyeing industry. Dispersant. Decolorizing deodorant for certain drugs. used as solvent, also used in rubber, Dye Industry
production method	is obtained by hydrogenation of furfural. When a nickel-chromium-copper based catalyst is used, the reaction temperature is from 170 to 180 ° C. And the pressure is from 7.5 to 10.5MPa. The furfural is obtained by continuous pressure hydrogenation at 170-180 ° C. And 7.355-7.845MPa in the presence of catalyst Ni.
category	flammable liquid
toxicity grade	poisoning
Acute toxicity	oral-rat LD50: 1600 mg/kg; Oral-mouse LD50: 2300 mg/kg
stimulation data	eye-rabbit 20 mg/24 h moderate
explosive hazard characteristics	explosive when mixed with air
flammability hazard characteristics	flammable in open flame, high temperature, strong oxidant; combustion emissions
storage and transportation characteristics	The package is complete, light, light; The warehouse is ventilated, away from open flame, high temperature, separate from oxidant
fire extinguishing agent	foam, carbon dioxide, water mist, sand, dry powder
spontaneous combustion temperature	282°C
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 20:49:11

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2-Hydroxymethyl oxolane

Tetrahydrofurfuryl alcohol

CAS: 97-99-4

Molecular Formula: C5H10O2

2-Hydroxymethyl oxolane - Names and Identifiers

2-Hydroxymethyl oxolane - Physico-chemical Properties

2-Hydroxymethyl oxolane - Risk and Safety

2-Hydroxymethyl oxolane - Nature

Open Data Verified Data

2-Hydroxymethyl oxolane - Preparation Method

Open Data Verified Data

2-Hydroxymethyl oxolane - Use

Open Data Verified Data

2-Hydroxymethyl oxolane - Safety

Open Data Verified Data

2-Hydroxymethyl oxolane - Reference Information

Supplier List

2-Hydroxymethyl oxolane Request for Quotation

Tetrahydrofurfuryl alcohol

CAS: 97-99-4

Molecular Formula: C5H10O2

2-Hydroxymethyl oxolane - Names and Identifiers

2-Hydroxymethyl oxolane - Physico-chemical Properties

2-Hydroxymethyl oxolane - Risk and Safety

2-Hydroxymethyl oxolane - Nature

Open Data Verified Data

2-Hydroxymethyl oxolane - Preparation Method

Open Data Verified Data

2-Hydroxymethyl oxolane - Use

Open Data Verified Data

2-Hydroxymethyl oxolane - Safety

Open Data Verified Data

2-Hydroxymethyl oxolane - Reference Information

Supplier List

2-Hydroxymethyl oxolane